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Unique characteristics of the naked mole-rat (NMR) have made it increasingly popular as a laboratory animal model. These rodents are used to study many fields of research including longevity and aging, cancer, circadian rhythm, pain, and metabolism. Currently, the analgesic dosing regimens used in the NMR mirror those used in other rodent species. However, there is no pharmacokinetic (PK) data supporting the use of injectable analgesics in the NMR. Therefore, we conducted two independent PK studies to evaluate two commonly used analgesics in the NMR; meloxicam (2 mg/kg SC) and buprenorphine (0.1 mg/kg SC). In each study, blood was collected at 8 time points after subcutaneous injection of meloxicam or buprenorphine (0 (pre-dose), 0.25, 0.5, 1, 2, 4, 8, and 24 hrs). Three NMRs were used per time point for a total of 24 animals per PK study. Plasma concentrations of meloxicam were highest between 0.5 hrs and 1 hr post-injection. Levels remained above the extrapolated dog and cat therapeutic threshold levels (390-911 ng/mL) for at least 24 hrs. Plasma concentrations of buprenorphine were highest between 0.25 and 0.5 hrs post-injection. Levels remained above the human therapeutic threshold (1 ng/mL) for up to 21 hrs. No skin reactions were seen in association with injection of either drug. In summary, this data supports dosing meloxicam (2 mg/kg SC) once every 24 hrs and buprenorphine (0.1 mg/kg SC) once every 8-12 hrs in the NMR. Further studies should be performed to evaluate the clinical efficacy of these drugs by correlating plasma concentrations with post-operative pain assessments.